About Neuromedin-U
Neuromedin-U (NMU) is a protein
from Homo sapiens identified by UniProt accession
P48645, 174 residues long.
MolForge cross-references it against 0 known binders and
159 disease associations.
Target properties
| Protein name | Neuromedin-U |
|---|
| UniProt accession | P48645 |
|---|
| Gene | NMU |
|---|
| Organism | Homo sapiens |
|---|
| Length | 174 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (159)
Diseases linked to this target (Open Targets).
- ovarian cancer · score 0.26
- BMI-adjusted waist-hip ratio · score 0.23
- arterial stiffness measurement · score 0.22
- lymphocyte count · score 0.12
- peak expiratory flow · score 0.11
- urinary albumin to creatinine ratio · score 0.07
- neoplasm · score 0.06
- papillary thyroid carcinoma · score 0.06
- obesity due to melanocortin 4 receptor deficiency · score 0.06
- body fat percentage · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48645-F1 | alphafold | PREDICTED | 62.73 | — |
Amino-acid sequence (174 residues)
MLRTESCRPR SPAGQVAAAS PLLLLLLLLA WCAGACRGAP ILPQGLQPEQ QLQLWNEIDD TCSSFLSIDS QPQASNALEE LCFMIMGMLP KPQEQDEKDN TKRFLFHYSK TQKLGKSNVV SSVVHPLLQL VPHLHERRMK RFRVDEEFQS PFASQSRGYF LFRPRNGRRS AGFI
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