About Phosphatidylserine synthase 1
Phosphatidylserine synthase 1 (PTDSS1) is a protein
from Homo sapiens identified by UniProt accession
P48651, 473 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Phosphatidylserine synthase 1 |
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| UniProt accession | P48651 |
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| Gene | PTDSS1 |
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| Organism | Homo sapiens |
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| Length | 473 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (68)
Diseases linked to this target (Open Targets).
- Lenz-Majewski hyperostotic dwarfism · score 0.77
- neurodegenerative disease · score 0.51
- multiple sclerosis · score 0.44
- Parkinson disease · score 0.44
- lysosomal storage disease · score 0.44
- Alzheimer disease · score 0.44
- type 2 diabetes mellitus · score 0.23
- peripheral arterial disease · score 0.23
- genetic disorder · score 0.19
- glioblastoma multiforme · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48651-F1 | alphafold | PREDICTED | 80.98 | — |
Amino-acid sequence (473 residues)
MASCVGSRTL SKDDVNYKMH FRMINEQQVE DITIDFFYRP HTITLLSFTI VSLMYFAFTR DDSVPEDNIW RGILSVIFFF LIISVLAFPN GPFTRPHPAL WRMVFGLSVL YFLFLVFLLF LNFEQVKSLM YWLDPNLRYA TREADVMEYA VNCHVITWER IISHFDIFAF GHFWGWAMKA LLIRSYGLCW TISITWELTE LFFMHLLPNF AECWWDQVIL DILLCNGGGI WLGMVVCRFL EMRTYHWASF KDIHTTTGKI KRAVLQFTPA SWTYVRWFDP KSSFQRVAGV YLFMIIWQLT ELNTFFLKHI FVFQASHPLS WGRILFIGGI TAPTVRQYYA YLTDTQCKRV GTQCWVFGVI GFLEAIVCIK FGQDLFSKTQ ILYVVLWLLC VAFTTFLCLY GMIWYAEHYG HREKTYSECE DGTYSPEISW HHRKGTKGSE DSPPKHAGNN ESHSSRRRNR HSKSKVTNGV GKK
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