About Excitatory amino acid transporter 4
Excitatory amino acid transporter 4 (SLC1A6) is a protein
from Homo sapiens identified by UniProt accession
P48664, 564 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | Excitatory amino acid transporter 4 |
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| UniProt accession | P48664 |
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| Gene | SLC1A6 |
|---|
| Organism | Homo sapiens |
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| Length | 564 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (57)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- thyroid gland adenocarcinoma · score 0.23
- hereditary neuropathy with liability to pressure palsies · score 0.05
- Charcot-Marie-Tooth disease type 2B2 · score 0.04
- autosomal dominant slowed nerve conduction velocity · score 0.04
- infection · score 0.03
- infect · score 0.03
- parkinsonism with polyneuropathy · score 0.03
- non-small cell lung carcinoma · score 0.03
- metabolite measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48664-F1 | alphafold | PREDICTED | 80.23 | — |
Amino-acid sequence (564 residues)
MSSHGNSLFL RESGQRLGRV GWLQRLQESL QQRALRTRLR LQTMTLEHVL RFLRRNAFIL LTVSAVVIGV SLAFALRPYQ LTYRQIKYFS FPGELLMRML QMLVLPLIVS SLVTGMASLD NKATGRMGMR AAVYYMVTTI IAVFIGILMV TIIHPGKGSK EGLHREGRIE TIPTADAFMD LIRNMFPPNL VEACFKQFKT QYSTRVVTRT MVRTENGSEP GASMPPPFSV ENGTSFLENV TRALGTLQEM LSFEETVPVP GSANGINALG LVVFSVAFGL VIGGMKHKGR VLRDFFDSLN EAIMRLVGII IWYAPVGILF LIAGKILEME DMAVLGGQLG MYTLTVIVGL FLHAGIVLPL IYFLVTHRNP FPFIGGMLQA LITAMGTSSS SATLPITFRC LEEGLGVDRR ITRFVLPVGA TVNMDGTALY EALAAIFIAQ VNNYELNLGQ ITTISITATA ASVGAAGIPQ AGLVTMVIVL TSVGLPTEDI TLIIAVDWFL DRLRTMTNVL GDSIGAAVIE HLSQRELELQ EAELTLPSLG KPYKSLMAQE KGASRGRGGN ESAM
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