About Keratin, type II cytoskeletal 6C
Keratin, type II cytoskeletal 6C (KRT6C) is a protein
from Homo sapiens identified by UniProt accession
P48668, 564 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Keratin, type II cytoskeletal 6C |
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| UniProt accession | P48668 |
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| Gene | KRT6C |
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| Organism | Homo sapiens |
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| Length | 564 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- palmoplantar keratoderma, nonepidermolytic, focal or diffuse · score 0.61
- Autosomal dominant focal non-epidermolytic palmoplantar keratoderma with plantar blistering · score 0.50
- Non-epidermolytic palmoplantar keratoderma · score 0.46
- focal palmoplantar keratoderma · score 0.42
- Palmoplantar keratoderma · score 0.37
- Nail dystrophy · score 0.37
- genetic disorder · score 0.19
- prostate adenocarcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
- ovarian cancer · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48668-F1 | alphafold | PREDICTED | 66.76 | — |
Amino-acid sequence (564 residues)
MASTSTTIRS HSSSRRGFSA NSARLPGVSR SGFSSISVSR SRGSGGLGGA CGGAGFGSRS LYGLGGSKRI SIGGGSCAIS GGYGSRAGGS YGFGGAGSGF GFGGGAGIGF GLGGGAGLAG GFGGPGFPVC PPGGIQEVTV NQSLLTPLNL QIDPAIQRVR AEEREQIKTL NNKFASFIDK VRFLEQQNKV LDTKWTLLQE QGTKTVRQNL EPLFEQYINN LRRQLDSIVG ERGRLDSELR NMQDLVEDLK NKYEDEINKR TAAENEFVTL KKDVDAAYMN KVELQAKADT LTDEINFLRA LYDAELSQMQ THISDTSVVL SMDNNRNLDL DSIIAEVKAQ YEEIAQRSRA EAESWYQTKY EELQVTAGRH GDDLRNTKQE IAEINRMIQR LRSEIDHVKK QCASLQAAIA DAEQRGEMAL KDAKNKLEGL EDALQKAKQD LARLLKEYQE LMNVKLALDV EIATYRKLLE GEECRLNGEG VGQVNVSVVQ STISSGYGGA SGVGSGLGLG GGSSYSYGSG LGIGGGFSSS SGRAIGGGLS SVGGGSSTIK YTTTSSSSRK SYKH
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