About Casein kinase I isoform delta
Casein kinase I isoform delta (CSNK1D) is a protein
from Homo sapiens identified by UniProt accession
P48730, 415 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Casein kinase I isoform delta |
|---|
| UniProt accession | P48730 |
|---|
| Gene | CSNK1D |
|---|
| Organism | Homo sapiens |
|---|
| Length | 415 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (69)
Diseases linked to this target (Open Targets).
- Familial advanced sleep-phase syndrome · score 0.62
- neurodegenerative disease · score 0.31
- hepatocellular carcinoma · score 0.10
- cancer · score 0.09
- neoplasm · score 0.08
- myeloid white cell count · score 0.05
- triple-negative breast cancer · score 0.03
- fatty acid measurement · score 0.03
- glioblastoma multiforme · score 0.02
- monocyte percentage of leukocytes · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48730-F1 | alphafold | PREDICTED | 81.01 | — |
Amino-acid sequence (415 residues)
MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH IESKIYKMMQ GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS HTANTSPRPV SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQI PGRVASSGLQ SVVHR
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