About Isocitrate dehydrogenase [NADP], mitochondrial
Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) is a protein
from Homo sapiens identified by UniProt accession
P48735, 452 residues long.
MolForge cross-references it against 0 known binders and
585 disease associations.
Target properties
| Protein name | Isocitrate dehydrogenase [NADP], mitochondrial |
|---|
| UniProt accession | P48735 |
|---|
| Gene | IDH2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 452 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (585)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.73
- D-2-hydroxyglutaric aciduria · score 0.72
- oligodendroglioma · score 0.62
- glioma susceptibility 1 · score 0.55
- myeloid neoplasm · score 0.49
- myelodysplastic syndrome · score 0.47
- hepatocellular carcinoma · score 0.44
- osteosarcoma · score 0.44
- urate measurement · score 0.43
- genetic disorder · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48735-F1 | alphafold | PREDICTED | 91.87 | — |
Amino-acid sequence (452 residues)
MAGYLRVVRS LCRASGSRPA WAPAALTAPT SQEQPRRHYA DKRIKVAKPV VEMDGDEMTR IIWQFIKEKL ILPHVDIQLK YFDLGLPNRD QTDDQVTIDS ALATQKYSVA VKCATITPDE ARVEEFKLKK MWKSPNGTIR NILGGTVFRE PIICKNIPRL VPGWTKPITI GRHAHGDQYK ATDFVADRAG TFKMVFTPKD GSGVKEWEVY NFPAGGVGMG MYNTDESISG FAHSCFQYAI QKKWPLYMST KNTILKAYDG RFKDIFQEIF DKHYKTDFDK NKIWYEHRLI DDMVAQVLKS SGGFVWACKN YDGDVQSDIL AQGFGSLGLM TSVLVCPDGK TIEAEAAHGT VTRHYREHQK GRPTSTNPIA SIFAWTRGLE HRGKLDGNQD LIRFAQMLEK VCVETVESGA MTKDLAGCIH GLSNVKLNEH FLNTTDFLDT IKSNLDRALG RQ
Explore Isocitrate dehydrogenase [NADP], mitochondrial with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets