About Phosphatidylinositol transfer protein beta isoform
Phosphatidylinositol transfer protein beta isoform (PITPNB) is a protein
from Homo sapiens identified by UniProt accession
P48739, 271 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Phosphatidylinositol transfer protein beta isoform |
|---|
| UniProt accession | P48739 |
|---|
| Gene | PITPNB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 271 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (62)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.29
- breast cancer · score 0.29
- insomnia · score 0.28
- total blood protein measurement · score 0.28
- body height · score 0.25
- glioblastoma multiforme · score 0.23
- urate measurement · score 0.23
- bone density · score 0.23
- BMI-adjusted waist-hip ratio · score 0.22
- mean corpuscular hemoglobin concentration · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48739-F1 | alphafold | PREDICTED | 95.40 | — |
Amino-acid sequence (271 residues)
MVLIKEFRVV LPCSVQEYQV GQLYSVAEAS KNETGGGEGI EVLKNEPYEK DGEKGQYTHK IYHLKSKVPA FVRMIAPEGS LVFHEKAWNA YPYCRTIVTN EYMKDDFFIK IETWHKPDLG TLENVHGLDP NTWKTVEIVH IDIADRSQVE PADYKADEDP ALFQSVKTKR GPLGPNWKKE LANSPDCPQM CAYKLVTIKF KWWGLQSKVE NFIQKQEKRI FTNFHRQLFC WIDKWIDLTM EDIRRMEDET QKELETMRKR GSVRGTSAAD V
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