LIM/homeobox protein Lhx1 (LHX1)

About LIM/homeobox protein Lhx1

LIM/homeobox protein Lhx1 (LHX1) is a protein from Homo sapiens identified by UniProt accession P48742, 406 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.

Target properties

Protein name	LIM/homeobox protein Lhx1
UniProt accession	P48742
Gene	LHX1
Organism	Homo sapiens
Length	406 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (77)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.56
brain volume measurement · score 0.34
metabolite measurement · score 0.26
high density lipoprotein cholesterol measurement · score 0.22
physical activity · score 0.22
genetic disorder · score 0.19
macrophage inflammatory protein 1b measurement · score 0.18
pulmonary tuberculosis · score 0.07
thyroid volume · score 0.05
46,XX ovotesticular disorder of sex development · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P48742-F1	alphafold	PREDICTED	66.73	—

Amino-acid sequence (406 residues)

MVHCAGCKRP ILDRFLLNVL DRAWHVKCVQ CCECKCNLTE KCFSREGKLY CKNDFFRCFG TKCAGCAQGI SPSDLVRRAR SKVFHLNCFT CMMCNKQLST GEELYIIDEN KFVCKEDYLS NSSVAKENSL HSATTGSDPS LSPDSQDPSQ DDAKDSESAN VSDKEAGSNE NDDQNLGAKR RGPRTTIKAK QLETLKAAFA ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ LSALGARRHA FFRSPRRMRP LVDRLEPGEL IPNGPFSFYG DYQSEYYGPG GNYDFFPQGP PSSQAQTPVD LPFVPSSGPS GTPLGGLEHP LPGHHPSSEA QRFTDILAHP PGDSPSPEPS LPGPLHSMSA EVFGPSPPFS SLSVNGGASY GNHLSHPPEM NEAAVW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards