About Anion exchange protein 3
Anion exchange protein 3 (SLC4A3) is a protein
from Homo sapiens identified by UniProt accession
P48751, 1232 residues long.
MolForge cross-references it against 0 known binders and
190 disease associations.
Target properties
| Protein name | Anion exchange protein 3 |
|---|
| UniProt accession | P48751 |
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| Gene | SLC4A3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 1232 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (190)
Diseases linked to this target (Open Targets).
- Familial short QT syndrome · score 0.42
- electrocardiography · score 0.41
- QT interval · score 0.34
- genetic disorder · score 0.19
- body height · score 0.19
- cortical thickness · score 0.19
- short QT syndrome · score 0.19
- Ventricular fibrillation · score 0.18
- ventricular fibrillation · score 0.18
- cardiac arrest · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48751-F1 | alphafold | PREDICTED | 66.67 | — |
Amino-acid sequence (1232 residues)
MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL ISKPPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP TSARHTRRKR KKEKTSAPPS EGTPPIQEEG GAGVDEEEEE EEEEEGESEA EPVEPPHSGT PQKAKFSIGS DEDDSPGLPG RAAVTKPLPS VGPHTDKSPQ HSSSSPSPRA RASRLAGEKS RPWSPSASYD LRERLCPGSA LGNPGGPEQQ VPTDEAEAQM LGSADLDDMK SHRLEDNPGV RRHLVKKPSR TQGGRGSPSG LAPILRRKKK KKKLDRRPHE VFVELNELML DRSQEPHWRE TARWIKFEED VEEETERWGK PHVASLSFRS LLELRRTIAH GAALLDLEQT TLPGIAHLVV ETMIVSDQIR PEDRASVLRT LLLKHSHPND DKDSGFFPRN PSSSSMNSVL GNHHPTPSHG PDGAVPTMAD DLGEPAPLWP HDPDAKEKPL HMPGGDGHRG KSLKLLEKIP EDAEATVVLV GCVPFLEQPA AAFVRLNEAV LLESVLEVPV PVRFLFVMLG PSHTSTDYHE LGRSIATLMS DKLFHEAAYQ ADDRQDLLSA ISEFLDGSIV IPPSEVEGRD LLRSVAAFQR ELLRKRRERE QTKVEMTTRG GYTAPGKELS LELGGSEATP EDDPLLRTGS VFGGLVRDVR RRYPHYPSDL RDALHSQCVA AVLFIYFAAL SPAITFGGLL GEKTEGLMGV SELIVSTAVL GVLFSLLGAQ PLLVVGFSGP LLVFEEAFFK FCRAQDLEYL TGRVWVGLWL VVFVLALVAA EGSFLVRYIS PFTQEIFAFL ISLIFIYETF YKLYKVFTEH PLLPFYPPEG ALEGSLDAGL EPNGSALPPT EGPPSPRNQP NTALLSLILM LGTFFIAFFL RKFRNSRFLG GKARRIIGDF GIPISILVMV LVDYSITDTY TQKLTVPTGL SVTSPDKRSW FIPPLGSARP FPPWMMVAAA VPALLVLILI FMETQITALI VSQKARRLLK GSGFHLDLLL IGSLGGLCGL FGLPWLTAAT VRSVTHVNAL TVMRTAIAPG DKPQIQEVRE QRVTGVLIAS LVGLSIVMGA VLRRIPLAVL FGIFLYMGVT SLSGIQLSQR LLLILMPAKH HPEQPYVTKV KTWRMHLFTC IQLGCIALLW VVKSTAASLA FPFLLLLTVP LRHCLLPRLF QDRELQALDS EDAEPNFDED GQDEYNELHM PV
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