About Troponin I, fast skeletal muscle
Troponin I, fast skeletal muscle (TNNI2) is a protein
from Homo sapiens identified by UniProt accession
P48788, 182 residues long.
MolForge cross-references it against 0 known binders and
183 disease associations.
Target properties
| Protein name | Troponin I, fast skeletal muscle |
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| UniProt accession | P48788 |
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| Gene | TNNI2 |
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| Organism | Homo sapiens |
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| Length | 182 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (183)
Diseases linked to this target (Open Targets).
- distal arthrogryposis type 2B1 · score 0.72
- Sheldon-hall syndrome · score 0.46
- arthrogryposis multiplex congenita · score 0.42
- distal arthrogryposis · score 0.41
- digitotalar dysmorphism · score 0.37
- amyotrophic lateral sclerosis · score 0.34
- Calcaneovalgus deformity · score 0.34
- Ulnar deviation of the wrist · score 0.34
- Congenital finger flexion contractures · score 0.34
- lung adenocarcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48788-F1 | alphafold | PREDICTED | 80.66 | — |
Amino-acid sequence (182 residues)
MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRREAE KQNYLAEHCP PLHIPGSMSE VQELCKQLHA KIDAAEEEKY DMEVRVQKTS KELEDMNQKL FDLRGKFKRP PLRRVRMSAD AMLKALLGSK HKVCMDLRAN LKQVKKEDTE KERDLRDVGD WRKNIEEKSG MEGRKKMFES ES
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