DNA polymerase delta subunit 2 (POLD2)

About DNA polymerase delta subunit 2

DNA polymerase delta subunit 2 (POLD2) is a protein from Homo sapiens identified by UniProt accession P49005, 469 residues long. MolForge cross-references it against 0 known binders and 310 disease associations.

Target properties

Protein name	DNA polymerase delta subunit 2
UniProt accession	P49005
Gene	POLD2
Organism	Homo sapiens
Length	469 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (310)

Diseases linked to this target (Open Targets).

acute myeloid leukemia · score 0.60
non-small cell lung carcinoma · score 0.60
acute lymphoblastic leukemia · score 0.60
ovarian cancer · score 0.60
pancreatic carcinoma · score 0.59
chronic lymphocytic leukemia · score 0.59
ovarian carcinoma · score 0.58
neoplasm · score 0.57
breast carcinoma · score 0.57
adult acute lymphoblastic leukemia · score 0.56

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49005-F1	alphafold	PREDICTED	89.06	—

Amino-acid sequence (469 residues)

MFSEQAAQRA HTLLSPPSAN NATFARVPVA TYTNSSQPFR LGERSFSRQY AHIYATRLIQ MRPFLENRAQ QHWGSGVGVK KLCELQPEEK CCVVGTLFKA MPLQPSILRE VSEEHNLLPQ PPRSKYIHPD DELVLEDELQ RIKLKGTIDV SKLVTGTVLA VFGSVRDDGK FLVEDYCFAD LAPQKPAPPL DTDRFVLLVS GLGLGGGGGE SLLGTQLLVD VVTGQLGDEG EQCSAAHVSR VILAGNLLSH STQSRDSINK AKYLTKKTQA ASVEAVKMLD EILLQLSASV PVDVMPGEFD PTNYTLPQQP LHPCMFPLAT AYSTLQLVTN PYQATIDGVR FLGTSGQNVS DIFRYSSMED HLEILEWTLR VRHISPTAPD TLGCYPFYKT DPFIFPECPH VYFCGNTPSF GSKIIRGPED QTVLLVTVPD FSATQTACLV NLRSLACQPI SFSGFGAEDD DLGGLGLGP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards