About MARCKS-related protein
MARCKS-related protein (MARCKSL1) is a protein
from Homo sapiens identified by UniProt accession
P49006, 195 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | MARCKS-related protein |
|---|
| UniProt accession | P49006 |
|---|
| Gene | MARCKSL1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 195 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (96)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- bone measurement · score 0.26
- bone density · score 0.20
- bone mineral content measurement · score 0.19
- anxiety · score 0.08
- esophageal squamous cell carcinoma · score 0.07
- schizencephaly · score 0.06
- nonpapillary renal cell carcinoma · score 0.05
- mirror movements 1 · score 0.05
- Barrett's esophagus · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49006-F1 | alphafold | PREDICTED | 54.87 | — |
Amino-acid sequence (195 residues)
MGSQSSKAPR GDVTAEEAAG ASPAKANGQE NGHVKSNGDL SPKGEGESPP VNGTDEAAGA TGDAIEPAPP SQGAEAKGEV PPKETPKKKK KFSFKKPFKL SGLSFKRNRK EGGGDSSASS PTEEEQEQGE IGACSDEGTA QEGKAAATPE SQEPQAKGAE ASAASEEEAG PQATEPSTPS GPESGPTPAS AEQNE
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