Hydroxycarboxylic acid receptor 3 (HCAR3)

About Hydroxycarboxylic acid receptor 3

Hydroxycarboxylic acid receptor 3 (HCAR3) is a protein from Homo sapiens identified by UniProt accession P49019, 387 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	Hydroxycarboxylic acid receptor 3
UniProt accession	P49019
Gene	HCAR3
Organism	Homo sapiens
Length	387 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (63)

Diseases linked to this target (Open Targets).

acute myeloid leukemia · score 0.37
Red cell distribution width · score 0.31
high density lipoprotein cholesterol measurement · score 0.31
apolipoprotein A 1 measurement · score 0.27
triglyceride measurement · score 0.27
glioblastoma multiforme · score 0.24
sleep duration · score 0.22
high altitude adaptation · score 0.19
BMI-adjusted hip circumference · score 0.18
HDL cholesterol change measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49019-F1	alphafold	PREDICTED	79.21	—

Amino-acid sequence (387 residues)

MNRHHLQDHF LEIDKKNCCV FRDDFIAKVL PPVLGLEFIF GLLGNGLALW IFCFHLKSWK SSRIFLFNLA VADFLLIICL PFVMDYYVRR SDWKFGDIPC RLVLFMFAMN RQGSIIFLTV VAVDRYFRVV HPHHALNKIS NWTAAIISCL LWGITVGLTV HLLKKKLLIQ NGTANVCISF SICHTFRWHE AMFLLEFFLP LGIILFCSAR IIWSLRQRQM DRHAKIKRAI TFIMVVAIVF VICFLPSVVV RIHIFWLLHT SGTQNCEVYR SVDLAFFITL SFTYMNSMLD PVVYYFSSPS FPNFFSTLIN RCLQRKITGE PDNNRSTSVE LTGDPNKTRG APEALIANSG EPWSPSYLGP TSNNHSKKGH CHQEPASLEK QLGCCIE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards