About MAP kinase-activated protein kinase 2
MAP kinase-activated protein kinase 2 (MAPKAPK2) is a protein
from Homo sapiens identified by UniProt accession
P49137, 400 residues long.
MolForge cross-references it against 0 known binders and
164 disease associations.
Target properties
| Protein name | MAP kinase-activated protein kinase 2 |
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| UniProt accession | P49137 |
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| Gene | MAPKAPK2 |
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| Organism | Homo sapiens |
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| Length | 400 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (164)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- neuroinflammatory disorder · score 0.39
- lysosomal storage disease · score 0.34
- glioblastoma multiforme · score 0.28
- MAP kinase-activated protein kinase 2 measurement · score 0.28
- mean corpuscular hemoglobin concentration · score 0.27
- mean corpuscular hemoglobin · score 0.24
- lung adenocarcinoma · score 0.23
- endometrial cancer · score 0.23
- cutaneous melanoma · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49137-F1 | alphafold | PREDICTED | 82.58 | — |
Amino-acid sequence (400 residues)
MLSNSQGQSP PVPFPAPAPP PQPPTPALPH PPAQPPPPPP QQFPQFHVKS GLQIKKNAII DDYKVTSQVL GLGINGKVLQ IFNKRTQEKF ALKMLQDCPK ARREVELHWR ASQCPHIVRI VDVYENLYAG RKCLLIVMEC LDGGELFSRI QDRGDQAFTE REASEIMKSI GEAIQYLHSI NIAHRDVKPE NLLYTSKRPN AILKLTDFGF AKETTSHNSL TTPCYTPYYV APEVLGPEKY DKSCDMWSLG VIMYILLCGY PPFYSNHGLA ISPGMKTRIR MGQYEFPNPE WSEVSEEVKM LIRNLLKTEP TQRMTITEFM NHPWIMQSTK VPQTPLHTSR VLKEDKERWE DVKEEMTSAL ATMRVDYEQI KIKKIEDASN PLLLKRRKKA RALEAAALAH
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