About Deoxyribonuclease-1-like 1
Deoxyribonuclease-1-like 1 (DNASE1L1) is a protein
from Homo sapiens identified by UniProt accession
P49184, 302 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Deoxyribonuclease-1-like 1 |
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| UniProt accession | P49184 |
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| Gene | DNASE1L1 |
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| Organism | Homo sapiens |
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| Length | 302 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (31)
Diseases linked to this target (Open Targets).
- Barth syndrome · score 0.53
- neurodegenerative disease · score 0.34
- Abnormality of the cardiovascular system · score 0.18
- left ventricular noncompaction · score 0.12
- dilated cardiomyopathy · score 0.12
- endocardial fibroelastosis · score 0.12
- cardiomyopathy · score 0.12
- hepatocellular carcinoma · score 0.03
- infection · score 0.03
- infect · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49184-F1 | alphafold | PREDICTED | 90.34 | — |
Amino-acid sequence (302 residues)
MHYPTALLFL ILANGAQAFR ICAFNAQRLT LAKVAREQVM DTLVRILARC DIMVLQEVVD SSGSAIPLLL RELNRFDGSG PYSTLSSPQL GRSTYMETYV YFYRSHKTQV LSSYVYNDED DVFAREPFVA QFSLPSNVLP SLVLVPLHTT PKAVEKELNA LYDVFLEVSQ HWQSKDVILL GDFNADCASL TKKRLDKLEL RTEPGFHWVI ADGEDTTVRA STHCTYDRVV LHGERCRSLL HTAAAFDFPT SFQLTEEEAL NISDHYPVEV ELKLSQAHSV QPLSLTVLLL LSLLSPQLCP AA
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