4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1)

About 4-trimethylaminobutyraldehyde dehydrogenase

4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) is a protein from Homo sapiens identified by UniProt accession P49189, 494 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	4-trimethylaminobutyraldehyde dehydrogenase
UniProt accession	P49189
Gene	ALDH9A1
Organism	Homo sapiens
Length	494 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.36
Alzheimer disease · score 0.30
multiple sclerosis · score 0.30
lysosomal storage disease · score 0.30
Parkinson disease · score 0.30
neuroinflammatory disorder · score 0.17
open-angle glaucoma · score 0.16
intraocular pressure measurement · score 0.16
glaucoma · score 0.16
drug use measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49189-F1	alphafold	PREDICTED	98.28	—

Amino-acid sequence (494 residues)

MSTGTFVVSQ PLNYRGGARV EPADASGTEK AFEPATGRVI ATFTCSGEKE VNLAVQNAKA AFKIWSQKSG MERCRILLEA ARIIREREDE IATMECINNG KSIFEARLDI DISWQCLEYY AGLAASMAGE HIQLPGGSFG YTRREPLGVC VGIGAWNYPF QIASWKSAPA LACGNAMVFK PSPFTPVSAL LLAEIYSEAG VPPGLFNVVQ GGAATGQFLC QHPDVAKVSF TGSVPTGMKI MEMSAKGIKP VTLELGGKSP LIIFSDCDMN NAVKGALMAN FLTQGQVCCN GTRVFVQKEI LDKFTEEVVK QTQRIKIGDP LLEDTRMGPL INRPHLERVL GFVKVAKEQG AKVLCGGDIY VPEDPKLKDG YYMRPCVLTN CRDDMTCVKE EIFGPVMSIL SFDTEAEVLE RANDTTFGLA AGVFTRDIQR AHRVVAELQA GTCFINNYNV SPVELPFGGY KKSGFGRENG RVTIEYYSQL KTVCVEMGDV ESAF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards