About Parathyroid hormone 2 receptor
Parathyroid hormone 2 receptor (PTH2R) is a protein
from Homo sapiens identified by UniProt accession
P49190, 550 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Parathyroid hormone 2 receptor |
|---|
| UniProt accession | P49190 |
|---|
| Gene | PTH2R |
|---|
| Organism | Homo sapiens |
|---|
| Length | 550 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (44)
Diseases linked to this target (Open Targets).
- hip bone mineral density · score 0.38
- age at menarche · score 0.34
- fat body mass · score 0.31
- adolescent idiopathic scoliosis · score 0.28
- syndromic intellectual disability · score 0.26
- ovarian cancer · score 0.18
- glioblastoma multiforme · score 0.17
- thyroid gland adenocarcinoma · score 0.16
- low grade glioma · score 0.10
- neoplasm · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49190-F1 | alphafold | PREDICTED | 71.65 | — |
Amino-acid sequence (550 residues)
MAGLGASLHV WGWLMLGSCL LARAQLDSDG TITIEEQIVL VLKAKVQCEL NITAQLQEGE GNCFPEWDGL ICWPRGTVGK ISAVPCPPYI YDFNHKGVAF RHCNPNGTWD FMHSLNKTWA NYSDCLRFLQ PDISIGKQEF FERLYVMYTV GYSISFGSLA VAILIIGYFR RLHCTRNYIH MHLFVSFMLR ATSIFVKDRV VHAHIGVKEL ESLIMQDDPQ NSIEATSVDK SQYIGCKIAV VMFIYFLATN YYWILVEGLY LHNLIFVAFF SDTKYLWGFI LIGWGFPAAF VAAWAVARAT LADARCWELS AGDIKWIYQA PILAAIGLNF ILFLNTVRVL ATKIWETNAV GHDTRKQYRK LAKSTLVLVL VFGVHYIVFV CLPHSFTGLG WEIRMHCELF FNSFQGFFVS IIYCYCNGEV QAEVKKMWSR WNLSVDWKRT PPCGSRRCGS VLTTVTHSTS SQSQVAASTR MVLISGKAAK IASRQPDSHI TLPGYVWSNS EQDCLPHSFH EETKEDSGRQ GDDILMEKPS RPMESNPDTE GCQGETEDVL
Explore Parathyroid hormone 2 receptor with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets