CX3C chemokine receptor 1 (CX3CR1)

About CX3C chemokine receptor 1

CX3C chemokine receptor 1 (CX3CR1) is a protein from Homo sapiens identified by UniProt accession P49238, 355 residues long. MolForge cross-references it against 0 known binders and 724 disease associations.

Target properties

Protein name	CX3C chemokine receptor 1
UniProt accession	P49238
Gene	CX3CR1
Organism	Homo sapiens
Length	355 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (724)

Diseases linked to this target (Open Targets).

monocyte count · score 0.47
lymphocyte count · score 0.46
leukocyte count · score 0.43
monocyte percentage of leukocytes · score 0.43
age-related macular degeneration · score 0.40
age related macular degeneration 12 · score 0.40
neutrophil percentage of leukocytes · score 0.38
myeloid white cell count · score 0.38
lymphocyte percentage of leukocytes · score 0.35
hypothyroidism · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49238-F1	alphafold	PREDICTED	80.52	—

Amino-acid sequence (355 residues)

MDQFPESVTE NFEYDDLAEA CYIGDIVVFG TVFLSIFYSV IFAIGLVGNL LVVFALTNSK KPKSVTDIYL LNLALSDLLF VATLPFWTHY LINEKGLHNA MCKFTTAFFF IGFFGSIFFI TVISIDRYLA IVLAANSMNN RTVQHGVTIS LGVWAAAILV AAPQFMFTKQ KENECLGDYP EVLQEIWPVL RNVETNFLGF LLPLLIMSYC YFRIIQTLFS CKNHKKAKAI KLILLVVIVF FLFWTPYNVM IFLETLKLYD FFPSCDMRKD LRLALSVTET VAFSHCCLNP LIYAFAGEKF RRYLYHLYGK CLAVLCGRSV HVDFSSSESQ RSRHGSVLSS NFTYHTSDGD ALLLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards