Ribose-5-phosphate isomerase (RPIA)

About Ribose-5-phosphate isomerase

Ribose-5-phosphate isomerase (RPIA) is a protein from Homo sapiens identified by UniProt accession P49247, 311 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	Ribose-5-phosphate isomerase
UniProt accession	P49247
Gene	RPIA
Organism	Homo sapiens
Length	311 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

ribose-5-P isomerase deficiency · score 0.76
Disorder of carbohydrate metabolism · score 0.46
genetic disorder · score 0.41
protein measurement · score 0.26
neurodegenerative disease · score 0.19
neuroinflammatory disorder · score 0.17
chronotype measurement · score 0.15
lean body mass · score 0.14
non-melanoma skin carcinoma · score 0.12
cerebellar volume measurement · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49247-F1	alphafold	PREDICTED	83.72	—

Amino-acid sequence (311 residues)

MQRPGPFSTL YGRVLAPLPG RAGGAASGGG GNSWDLPGSH VRLPGRAQSG TRGGAGNTST SCGDSNSICP APSTMSKAEE AKKLAGRAAV ENHVRNNQVL GIGSGSTIVH AVQRIAERVK QENLNLVCIP TSFQARQLIL QYGLTLSDLD RHPEIDLAID GADEVDADLN LIKGGGGCLT QEKIVAGYAS RFIVIADFRK DSKNLGDQWH KGIPIEVIPM AYVPVSRAVS QKFGGVVELR MAVNKAGPVV TDNGNFILDW KFDRVHKWSE VNTAIKMIPG VVDTGLFINM AERVYFGMQD GSVNMREKPF C

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards