Protein ERGIC-53 (LMAN1)

About Protein ERGIC-53

Protein ERGIC-53 (LMAN1) is a protein from Homo sapiens identified by UniProt accession P49257, 510 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.

Target properties

Protein name	Protein ERGIC-53
UniProt accession	P49257
Gene	LMAN1
Organism	Homo sapiens
Length	510 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (78)

Diseases linked to this target (Open Targets).

factor V and factor VIII, combined deficiency of, type 1 · score 0.72
combined deficiency of factor V and factor VIII · score 0.37
cardiac troponin I measurement · score 0.36
neurodegenerative disease · score 0.32
IGF-1 measurement · score 0.31
eosinophil count · score 0.20
genetic disorder · score 0.19
late-onset Alzheimers disease · score 0.14
cutaneous melanoma · score 0.14
appendicular lean mass · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49257-F1	alphafold	PREDICTED	79.39	—

Amino-acid sequence (510 residues)

MAGSRQRGLR ARVRPLFCAL LLSLGRFVRG DGVGGDPAVA LPHRRFEYKY SFKGPHLVQS DGTVPFWAHA GNAIPSSDQI RVAPSLKSQR GSVWTKTKAA FENWEVEVTF RVTGRGRIGA DGLAIWYAEN QGLEGPVFGS ADLWNGVGIF FDSFDNDGKK NNPAIVIIGN NGQIHYDHQN DGASQALASC QRDFRNKPYP VRAKITYYQN TLTVMINNGF TPDKNDYEFC AKVENMIIPA QGHFGISAAT GGLADDHDVL SFLTFQLTEP GKEPPTPDKE ISEKEKEKYQ EEFEHFQQEL DKKKEEFQKG HPDLQGQPAE EIFESVGDRE LRQVFEGQNR IHLEIKQLNR QLDMILDEQR RYVSSLTEEI SKRGAGMPGQ HGQITQQELD TVVKTQHEIL RQVNEMKNSM SETVRLVSGM QHPGSAGGVY ETTQHFIDIK EHLHIVKRDI DNLVQRNMPS NEKPKCPELP PFPSCLSTVH FIIFVVVQTV LFIGYIMYRS QQEAAAKKFF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards