About Natural resistance-associated macrophage protein 1
Natural resistance-associated macrophage protein 1 (SLC11A1) is a protein
from Homo sapiens identified by UniProt accession
P49279, 550 residues long.
MolForge cross-references it against 0 known binders and
257 disease associations.
Target properties
| Protein name | Natural resistance-associated macrophage protein 1 |
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| UniProt accession | P49279 |
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| Gene | SLC11A1 |
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| Organism | Homo sapiens |
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| Length | 550 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (257)
Diseases linked to this target (Open Targets).
- cystic fibrosis · score 0.37
- Buruli ulcer disease · score 0.19
- lung adenocarcinoma · score 0.18
- ovarian cancer · score 0.18
- glioblastoma multiforme · score 0.18
- squamous cell lung carcinoma · score 0.14
- tuberculosis · score 0.13
- head and neck squamous cell carcinoma · score 0.12
- genetic disorder · score 0.12
- immunodeficiency 28 · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49279-F1 | alphafold | PREDICTED | 83.03 | — |
Amino-acid sequence (550 residues)
MTGDKGPQRL SGSSYGSISS PTSPTSPGPQ QAPPRETYLS EKIPIPDTKP GTFSLRKLWA FTGPGFLMSI AFLDPGNIES DLQAGAVAGF KLLWVLLWAT VLGLLCQRLA ARLGVVTGKD LGEVCHLYYP KVPRTVLWLT IELAIVGSDM QEVIGTAIAF NLLSAGRIPL WGGVLITIVD TFFFLFLDNY GLRKLEAFFG LLITIMALTF GYEYVVARPE QGALLRGLFL PSCPGCGHPE LLQAVGIVGA IIMPHNIYLH SALVKSREID RARRADIREA NMYFLIEATI ALSVSFIINL FVMAVFGQAF YQKTNQAAFN ICANSSLHDY AKIFPMNNAT VAVDIYQGGV ILGCLFGPAA LYIWAIGLLA AGQSSTMTGT YAGQFVMEGF LRLRWSRFAR VLLTRSCAIL PTVLVAVFRD LRDLSGLNDL LNVLQSLLLP FAVLPILTFT SMPTLMQEFA NGLLNKVVTS SIMVLVCAIN LYFVVSYLPS LPHPAYFGLA ALLAAAYLGL STYLVWTCCL AHGATFLAHS SHHHFLYGLL EEDQKGETSG
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