About Natural resistance-associated macrophage protein 2
Natural resistance-associated macrophage protein 2 (SLC11A2) is a protein
from Homo sapiens identified by UniProt accession
P49281, 568 residues long.
MolForge cross-references it against 0 known binders and
309 disease associations.
Target properties
| Protein name | Natural resistance-associated macrophage protein 2 |
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| UniProt accession | P49281 |
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| Gene | SLC11A2 |
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| Organism | Homo sapiens |
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| Length | 568 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (309)
Diseases linked to this target (Open Targets).
- microcytic anemia with liver iron overload · score 0.77
- Hypochromic microcytic anemia · score 0.37
- mean corpuscular hemoglobin concentration · score 0.23
- genetic disorder · score 0.19
- mean corpuscular hemoglobin · score 0.15
- functional brain measurement · score 0.14
- Blackfan-Diamond anemia · score 0.08
- hemoglobin D disease · score 0.08
- X-linked sideroblastic anemia 1 · score 0.07
- Congenital dyserythropoietic anemia type I · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49281-F1 | alphafold | PREDICTED | 80.60 | — |
Amino-acid sequence (568 residues)
MVLGPEQKMS DDSVSGDHGE SASLGNINPA YSNPSLSQSP GDSEEYFATY FNEKISIPEE EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA GFKLLWILLL ATLVGLLLQR LAARLGVVTG LHLAEVCHRQ YPKVPRVILW LMVELAIIGS DMQEVIGSAI AINLLSVGRI PLWGGVLITI ADTFVFLFLD KYGLRKLEAF FGFLITIMAL TFGYEYVTVK PSQSQVLKGM FVPSCSGCRT PQIEQAVGIV GAVIMPHNMY LHSALVKSRQ VNRNNKQEVR EANKYFFIES CIALFVSFII NVFVVSVFAE AFFGKTNEQV VEVCTNTSSP HAGLFPKDNS TLAVDIYKGG VVLGCYFGPA ALYIWAVGIL AAGQSSTMTG TYSGQFVMEG FLNLKWSRFA RVVLTRSIAI IPTLLVAVFQ DVEHLTGMND FLNVLQSLQL PFALIPILTF TSLRPVMSDF ANGLGWRIAG GILVLIICSI NMYFVVVYVR DLGHVALYVV AAVVSVAYLG FVFYLGWQCL IALGMSFLDC GHTCHLGLTA QPELYLLNTM DADSLVSR
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