Melatonin receptor type 1B (MTNR1B)

About Melatonin receptor type 1B

Melatonin receptor type 1B (MTNR1B) is a protein from Homo sapiens identified by UniProt accession P49286, 362 residues long. MolForge cross-references it against 0 known binders and 263 disease associations.

Target properties

Protein name	Melatonin receptor type 1B
UniProt accession	P49286
Gene	MTNR1B
Organism	Homo sapiens
Length	362 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (263)

Diseases linked to this target (Open Targets).

insomnia · score 0.60
delirium · score 0.58
chronotype measurement · score 0.57
schizophrenia · score 0.56
type 2 diabetes mellitus · score 0.56
major depressive disorder · score 0.55
Sleep Disorder · score 0.54
anxiety · score 0.54
sleep-wake disorder · score 0.53
fasting blood glucose measurement · score 0.53

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49286-F1	alphafold	PREDICTED	84.00	—

Amino-acid sequence (362 residues)

MSENGSFANC CEAGGWAVRP GWSGAGSARP SRTPRPPWVA PALSAVLIVT TAVDVVGNLL VILSVLRNRK LRNAGNLFLV SLALADLVVA FYPYPLILVA IFYDGWALGE EHCKASAFVM GLSVIGSVFN ITAIAINRYC YICHSMAYHR IYRRWHTPLH ICLIWLLTVV ALLPNFFVGS LEYDPRIYSC TFIQTASTQY TAAVVVIHFL LPIAVVSFCY LRIWVLVLQA RRKAKPESRL CLKPSDLRSF LTMFVVFVIF AICWAPLNCI GLAVAINPQE MAPQIPEGLF VTSYLLAYFN SCLNAIVYGL LNQNFRREYK RILLALWNPR HCIQDASKGS HAEGLQSPAP PIIGVQHQAD AL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards