About Cyclin-dependent kinase 8
Cyclin-dependent kinase 8 (CDK8) is a protein
from Homo sapiens identified by UniProt accession
P49336, 464 residues long.
MolForge cross-references it against 0 known binders and
189 disease associations.
Target properties
| Protein name | Cyclin-dependent kinase 8 |
|---|
| UniProt accession | P49336 |
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| Gene | CDK8 |
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| Organism | Homo sapiens |
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| Length | 464 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (189)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder with hypotonia and behavioral abnormalities · score 0.76
- syndromic intellectual disability · score 0.46
- cancer · score 0.39
- neuroinflammatory disorder · score 0.37
- complex neurodevelopmental disorder · score 0.37
- neurodegenerative disease · score 0.36
- Ebstein anomaly · score 0.34
- Stillbirth · score 0.34
- Abnormal heart morphology · score 0.34
- Abnormal facial shape · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49336-F1 | alphafold | PREDICTED | 79.82 | — |
Amino-acid sequence (464 residues)
MDYDFKVKLS SERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKANKKP VQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED IKTSNPYHHD QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH KVKPDSKAFH LLQKLLTMDP IKRITSEQAM QDPYFLEDPL PTSDVFAGCQ IPYPKREFLT EEEPDDKGDK KNQQQQQGNN HTNGTGHPGN QDSSHTQGPP LKKVRVVPPT TTSGGLIMTS DYQRSNPHAA YPNPGPSTSQ PQSSMGYSAT SQQPPQYSHQ THRY
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