About Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) is a protein
from Homo sapiens identified by UniProt accession
P49354, 379 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
|---|
| UniProt accession | P49354 |
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| Gene | FNTA |
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| Organism | Homo sapiens |
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| Length | 379 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (120)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- Hutchinson-Gilford progeria syndrome · score 0.47
- progeria · score 0.40
- hepatitis D virus infection · score 0.34
- myelodysplastic syndrome · score 0.34
- acute myeloid leukemia · score 0.29
- non-small cell lung carcinoma · score 0.29
- chronic myelomonocytic leukemia · score 0.28
- ovarian cancer · score 0.27
- acute myelomonocytic leukemia · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49354-F1 | alphafold | PREDICTED | 87.67 | — |
Amino-acid sequence (379 residues)
MAATEGVGEA AQGGEPGQPA QPPPQPHPPP PQQQHKEEMA AEAGEAVASP MDDGFVSLDS PSYVLYRDRA EWADIDPVPQ NDGPNPVVQI IYSDKFRDVY DYFRAVLQRD ERSERAFKLT RDAIELNAAN YTVWHFRRVL LKSLQKDLHE EMNYITAIIE EQPKNYQVWH HRRVLVEWLR DPSQELEFIA DILNQDAKNY HAWQHRQWVI QEFKLWDNEL QYVDQLLKED VRNNSVWNQR YFVISNTTGY NDRAVLEREV QYTLEMIKLV PHNESAWNYL KGILQDRGLS KYPNLLNQLL DLQPSHSSPY LIAFLVDIYE DMLENQCDNK EDILNKALEL CEILAKEKDT IRKEYWRYIG RSLQSKHSTE NDSPTNVQQ
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