About Protein farnesyltransferase subunit beta
Protein farnesyltransferase subunit beta (FNTB) is a protein
from Homo sapiens identified by UniProt accession
P49356, 437 residues long.
MolForge cross-references it against 0 known binders and
140 disease associations.
Target properties
| Protein name | Protein farnesyltransferase subunit beta |
|---|
| UniProt accession | P49356 |
|---|
| Gene | FNTB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 437 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (140)
Diseases linked to this target (Open Targets).
- Hutchinson-Gilford progeria syndrome · score 0.47
- progeria · score 0.40
- mean corpuscular hemoglobin concentration · score 0.38
- mean corpuscular hemoglobin · score 0.37
- erythrocyte count · score 0.37
- mean corpuscular volume · score 0.37
- platelet count · score 0.35
- hepatitis D virus infection · score 0.34
- mean platelet volume · score 0.34
- hemoglobin measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49356-F1 | alphafold | PREDICTED | 94.61 | — |
Amino-acid sequence (437 residues)
MASPSSFTYY CPPSSSPVWS EPLYSLRPEH ARERLQDDSV ETVTSIEQAK VEEKIQEVFS SYKFNHLVPR LVLQREKHFH YLKRGLRQLT DAYECLDASR PWLCYWILHS LELLDEPIPQ IVATDVCQFL ELCQSPEGGF GGGPGQYPHL APTYAAVNAL CIIGTEEAYD IINREKLLQY LYSLKQPDGS FLMHVGGEVD VRSAYCAASV ASLTNIITPD LFEGTAEWIA RCQNWEGGIG GVPGMEAHGG YTFCGLAALV ILKRERSLNL KSLLQWVTSR QMRFEGGFQG RCNKLVDGCY SFWQAGLLPL LHRALHAQGD PALSMSHWMF HQQALQEYIL MCCQCPAGGL LDKPGKSRDF YHTCYCLSGL SIAQHFGSGA MLHDVVLGVP ENALQPTHPV YNIGPDKVIQ ATTYFLQKPV PGFEELKDET SAEPATD
Explore Protein farnesyltransferase subunit beta with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets