Deoxyhypusine synthase (DHPS)

About Deoxyhypusine synthase

Deoxyhypusine synthase (DHPS) is a protein from Homo sapiens identified by UniProt accession P49366, 369 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.

Target properties

Protein name	Deoxyhypusine synthase
UniProt accession	P49366
Gene	DHPS
Organism	Homo sapiens
Length	369 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (128)

Diseases linked to this target (Open Targets).

syndromic intellectual disability · score 0.58
Global developmental delay · score 0.47
Intellectual disability · score 0.46
Seizure · score 0.46
Atypical behavior · score 0.46
Abnormality of head or neck · score 0.46
EEG abnormality · score 0.46
Abnormal muscle tone · score 0.46
neurodegenerative disease · score 0.46
familial hypercholesterolemia · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49366-F1	alphafold	PREDICTED	94.08	—

Amino-acid sequence (369 residues)

MEGSLEREAP AGALAAVLKH SSTLPPESTQ VRGYDFNRGV NYRALLEAFG TTGFQATNFG RAVQQVNAMI EKKLEPLSQD EDQHADLTQS RRPLTSCTIF LGYTSNLISS GIRETIRYLV QHNMVDVLVT TAGGVEEDLI KCLAPTYLGE FSLRGKELRE NGINRIGNLL VPNENYCKFE DWLMPILDQM VMEQNTEGVK WTPSKMIARL GKEINNPESV YYWAQKNHIP VFSPALTDGS LGDMIFFHSY KNPGLVLDIV EDLRLINTQA IFAKCTGMII LGGGVVKHHI ANANLMRNGA DYAVYINTAQ EFDGSDSGAR PDEAVSWGKI RVDAQPVKVY ADASLVFPLL VAETFAQKMD AFMHEKNED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards