T-complex protein 1 subunit gamma (CCT3)

About T-complex protein 1 subunit gamma

T-complex protein 1 subunit gamma (CCT3) is a protein from Homo sapiens identified by UniProt accession P49368, 545 residues long. MolForge cross-references it against 0 known binders and 173 disease associations.

Target properties

Protein name	T-complex protein 1 subunit gamma
UniProt accession	P49368
Gene	CCT3
Organism	Homo sapiens
Length	545 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (173)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.47
lung adenocarcinoma · score 0.28
head and neck squamous cell carcinoma · score 0.27
ovarian cancer · score 0.27
endometrial cancer · score 0.25
esophageal cancer · score 0.25
gastric adenocarcinoma · score 0.25
neuroinflammatory disorder · score 0.25
breast adenocarcinoma · score 0.25
urinary bladder cancer · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49368-F1	alphafold	PREDICTED	89.06	—

Amino-acid sequence (545 residues)

MMGHRPVLVL SQNTKRESGR KVQSGNINAA KTIADIIRTC LGPKSMMKML LDPMGGIVMT NDGNAILREI QVQHPAAKSM IEISRTQDEE VGDGTTSVII LAGEMLSVAE HFLEQQMHPT VVISAYRKAL DDMISTLKKI SIPVDISDSD MMLNIINSSI TTKAISRWSS LACNIALDAV KMVQFEENGR KEIDIKKYAR VEKIPGGIIE DSCVLRGVMI NKDVTHPRMR RYIKNPRIVL LDSSLEYKKG ESQTDIEITR EEDFTRILQM EEEYIQQLCE DIIQLKPDVV ITEKGISDLA QHYLMRANIT AIRRVRKTDN NRIARACGAR IVSRPEELRE DDVGTGAGLL EIKKIGDEYF TFITDCKDPK ACTILLRGAS KEILSEVERN LQDAMQVCRN VLLDPQLVPG GGASEMAVAH ALTEKSKAMT GVEQWPYRAV AQALEVIPRT LIQNCGASTI RLLTSLRAKH TQENCETWGV NGETGTLVDM KELGIWEPLA VKLQTYKTAV ETAVLLLRID DIVSGHKKKG DDQSRQGGAP DAGQE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards