Beta-arrestin-1 (ARRB1)

About Beta-arrestin-1

Beta-arrestin-1 (ARRB1) is a protein from Homo sapiens identified by UniProt accession P49407, 418 residues long. MolForge cross-references it against 0 known binders and 249 disease associations.

Target properties

Protein name	Beta-arrestin-1
UniProt accession	P49407
Gene	ARRB1
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (249)

Diseases linked to this target (Open Targets).

cancer · score 0.61
Noonan syndrome · score 0.53
hypertrophic cardiomyopathy · score 0.52
Costello syndrome · score 0.50
cardiofaciocutaneous syndrome · score 0.37
thyroid gland adenocarcinoma · score 0.30
lung adenocarcinoma · score 0.29
breast adenocarcinoma · score 0.29
neoplasm · score 0.28
protein measurement · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49407-F1	alphafold	PREDICTED	82.17	—

Amino-acid sequence (418 residues)

MGDKGTRVFK KASPNGKLTV YLGKRDFVDH IDLVDPVDGV VLVDPEYLKE RRVYVTLTCA FRYGREDLDV LGLTFRKDLF VANVQSFPPA PEDKKPLTRL QERLIKKLGE HAYPFTFEIP PNLPCSVTLQ PGPEDTGKAC GVDYEVKAFC AENLEEKIHK RNSVRLVIRK VQYAPERPGP QPTAETTRQF LMSDKPLHLE ASLDKEIYYH GEPISVNVHV TNNTNKTVKK IKISVRQYAD ICLFNTAQYK CPVAMEEADD TVAPSSTFCK VYTLTPFLAN NREKRGLALD GKLKHEDTNL ASSTLLREGA NREILGIIVS YKVKVKLVVS RGGLLGDLAS SDVAVELPFT LMHPKPKEEP PHREVPENET PVDTNLIELD TNDDDIVFED FARQRLKGMK DDKEEEEDGT GSPQLNNR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards