Elongation factor Tu, mitochondrial (TUFM)

About Elongation factor Tu, mitochondrial

Elongation factor Tu, mitochondrial (TUFM) is a protein from Homo sapiens identified by UniProt accession P49411, 455 residues long. MolForge cross-references it against 0 known binders and 145 disease associations.

Target properties

Protein name	Elongation factor Tu, mitochondrial
UniProt accession	P49411
Gene	TUFM
Organism	Homo sapiens
Length	455 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (145)

Diseases linked to this target (Open Targets).

combined oxidative phosphorylation defect type 4 · score 0.76
neurodegenerative disease · score 0.50
COVID-19 · score 0.46
genetic disorder · score 0.19
mitochondrial disease · score 0.18
red blood cell density measurement · score 0.18
lean body mass · score 0.18
body mass index · score 0.17
intelligence · score 0.17
body fat percentage · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49411-F1	alphafold	PREDICTED	85.03	—

Amino-acid sequence (455 residues)

MTTMAAATLL RATPHFSGLA AGRTFLLQGL LRLLKAPALP LLCRGLAVEA KKTYVRDKPH VNVGTIGHVD HGKTTLTAAI TKILAEGGGA KFKKYEEIDN APEERARGIT INAAHVEYST AARHYAHTDC PGHADYVKNM ITGTAPLDGC ILVVAANDGP MPQTREHLLL ARQIGVEHVV VYVNKADAVQ DSEMVELVEL EIRELLTEFG YKGEETPVIV GSALCALEGR DPELGLKSVQ KLLDAVDTYI PVPARDLEKP FLLPVEAVYS VPGRGTVVTG TLERGILKKG DECELLGHSK NIRTVVTGIE MFHKSLERAE AGDNLGALVR GLKREDLRRG LVMVKPGSIK PHQKVEAQVY ILSKEEGGRH KPFVSHFMPV MFSLTWDMAC RIILPPEKEL AMPGEDLKFN LILRQPMILE KGQRFTLRDG NRTIGTGLVT NTLAMTEEEK NIKWG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards