About Alpha-aminoadipic semialdehyde dehydrogenase
Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) is a protein
from Homo sapiens identified by UniProt accession
P49419, 539 residues long.
MolForge cross-references it against 0 known binders and
522 disease associations.
Target properties
| Protein name | Alpha-aminoadipic semialdehyde dehydrogenase |
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| UniProt accession | P49419 |
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| Gene | ALDH7A1 |
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| Organism | Homo sapiens |
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| Length | 539 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (522)
Diseases linked to this target (Open Targets).
- pyridoxine-dependent epilepsy · score 0.78
- pyridoxine-dependent epilepsy caused by ALDH7A1 mutant · score 0.71
- genetic disorder · score 0.53
- Seizure · score 0.49
- Ventriculomegaly · score 0.43
- developmental and epileptic encephalopathy · score 0.38
- galactose epimerase deficiency · score 0.34
- hereditary breast ovarian cancer syndrome · score 0.34
- adult-onset autosomal dominant demyelinating leukodystrophy · score 0.34
- Hereditary breast and ovarian cancer syndrome · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49419-F1 | alphafold | PREDICTED | 95.16 | — |
Amino-acid sequence (539 residues)
MWRLPRALCV HAAKTSKLSG PWSRPAAFMS TLLINQPQYA WLKELGLREE NEGVYNGSWG GRGEVITTYC PANNEPIARV RQASVADYEE TVKKAREAWK IWADIPAPKR GEIVRQIGDA LREKIQVLGS LVSLEMGKIL VEGVGEVQEY VDICDYAVGL SRMIGGPILP SERSGHALIE QWNPVGLVGI ITAFNFPVAV YGWNNAIAMI CGNVCLWKGA PTTSLISVAV TKIIAKVLED NKLPGAICSL TCGGADIGTA MAKDERVNLL SFTGSTQVGK QVGLMVQERF GRSLLELGGN NAIIAFEDAD LSLVVPSALF AAVGTAGQRC TTARRLFIHE SIHDEVVNRL KKAYAQIRVG NPWDPNVLYG PLHTKQAVSM FLGAVEEAKK EGGTVVYGGK VMDRPGNYVE PTIVTGLGHD ASIAHTETFA PILYVFKFKN EEEVFAWNNE VKQGLSSSIF TKDLGRIFRW LGPKGSDCGI VNVNIPTSGA EIGGAFGGEK HTGGGRESGS DAWKQYMRRS TCTINYSKDL PLAQGIKFQ
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