Ubiquitin-conjugating enzyme E2 R1 (CDC34)

About Ubiquitin-conjugating enzyme E2 R1

Ubiquitin-conjugating enzyme E2 R1 (CDC34) is a protein from Homo sapiens identified by UniProt accession P49427, 236 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.

Target properties

Protein name	Ubiquitin-conjugating enzyme E2 R1
UniProt accession	P49427
Gene	CDC34
Organism	Homo sapiens
Length	236 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (90)

Diseases linked to this target (Open Targets).

azoospermia · score 0.07
neoplasm · score 0.06
non-small cell lung carcinoma · score 0.06
MODY · score 0.06
male infertility with teratozoospermia due to single gene mutation · score 0.05
partial chromosome Y deletion · score 0.05
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.05
spermatogenic failure 61 · score 0.05
spermatogenic failure 3 · score 0.05
spermatogenic failure 55 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49427-F1	alphafold	PREDICTED	85.07	—

Amino-acid sequence (236 residues)

MARPLVPSSQ KALLLELKGL QEEPVEGFRV TLVDEGDLYN WEVAIFGPPN TYYEGGYFKA RLKFPIDYPY SPPAFRFLTK MWHPNIYETG DVCISILHPP VDDPQSGELP SERWNPTQNV RTILLSVISL LNEPNTFSPA NVDASVMYRK WKESKGKDRE YTDIIRKQVL GTKVDAERDG VKVPTTLAEY CVKTKAPAPD EGSDLFYDDY YEDGEVEEEA DSCFGDDEDD SGTEES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards