About Inositol polyphosphate 1-phosphatase
Inositol polyphosphate 1-phosphatase (INPP1) is a protein
from Homo sapiens identified by UniProt accession
P49441, 399 residues long.
MolForge cross-references it against 0 known binders and
100 disease associations.
Target properties
| Protein name | Inositol polyphosphate 1-phosphatase |
|---|
| UniProt accession | P49441 |
|---|
| Gene | INPP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 399 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (100)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.38
- neuroinflammatory disorder · score 0.22
- glioblastoma multiforme · score 0.18
- blood protein measurement · score 0.13
- lung carcinoma · score 0.12
- Cleft palate · score 0.11
- retinopathy · score 0.11
- urinary metabolite measurement · score 0.11
- Fuchs endothelial corneal dystrophy · score 0.08
- Lisch epithelial corneal dystrophy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49441-F1 | alphafold | PREDICTED | 87.68 | — |
Amino-acid sequence (399 residues)
MSDILRELLC VSEKAANIAR ACRQQEALFQ LLIEEKKEGE KNKKFAVDFK TLADVLVQEV IKQNMENKFP GLEKNIFGEE SNEFTNDWGE KITLRLCSTE EETAELLSKV LNGNKVASEA LARVVHQDVA FTDPTLDSTE INVPQDILGI WVDPIDSTYQ YIKGSADIKS NQGIFPCGLQ CVTILIGVYD IQTGVPLMGV INQPFVSRDP NTLRWKGQCY WGLSYMGTNM HSLQLTISRR NGSETHTGNT GSEAAFSPSF SAVISTSEKE TIKAALSRVC GDRIFGAAGA GYKSLCVVQG LVDIYIFSED TTFKWDSCAA HAILRAMGGG IVDLKECLER NPETGLDLPQ LVYHVENEGA AGVDRWANKG GLIAYRSRKR LETFLSLLVQ NLAPAETHT
Explore Inositol polyphosphate 1-phosphatase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets