About Transmembrane ascorbate-dependent reductase CYB561
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) is a protein
from Homo sapiens identified by UniProt accession
P49447, 251 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | Transmembrane ascorbate-dependent reductase CYB561 |
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| UniProt accession | P49447 |
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| Gene | CYB561 |
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| Organism | Homo sapiens |
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| Length | 251 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (74)
Diseases linked to this target (Open Targets).
- orthostatic hypotension · score 0.51
- late-onset Alzheimers disease · score 0.13
- cholesterol esters in large HDL measurement · score 0.10
- risk-taking behaviour · score 0.09
- intelligence · score 0.09
- worry measurement · score 0.07
- diastolic blood pressure · score 0.06
- breast cancer · score 0.06
- hypertension · score 0.06
- cardiovascular disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49447-F1 | alphafold | PREDICTED | 92.75 | — |
Amino-acid sequence (251 residues)
MEGGAAAATP TALPYYVAFS QLLGLTLVAM TGAWLGLYRG GIAWESDLQF NAHPLCMVIG LIFLQGNALL VYRVFRNEAK RTTKVLHGLL HIFALVIALV GLVAVFDYHR KKGYADLYSL HSWCGILVFV LYFVQWLVGF SFFLFPGASF SLRSRYRPQH IFFGATIFLL SVGTALLGLK EALLFNLGGK YSAFEPEGVL ANVLGLLLAC FGGAVLYILT RADWKRPSQA EEQALSMDFK TLTEGDSPGS Q
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