Histone H3-like centromeric protein A (CENPA)

About Histone H3-like centromeric protein A

Histone H3-like centromeric protein A (CENPA) is a protein from Homo sapiens identified by UniProt accession P49450, 140 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

Target properties

Protein name	Histone H3-like centromeric protein A
UniProt accession	P49450
Gene	CENPA
Organism	Homo sapiens
Length	140 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
body mass index · score 0.12
hepatocellular carcinoma · score 0.12
neoplasm · score 0.11
lean body mass · score 0.10
body fat percentage · score 0.10
fat body mass · score 0.10
age at first sexual intercourse measurement · score 0.09
cancer · score 0.09
cervical squamous intraepithelial neoplasia · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49450-F1	alphafold	PREDICTED	81.49	—

Amino-acid sequence (140 residues)

MGPRRRSRKP EAPRRRSPSP TPTPGPSRRG PSLGASSHQH SRRRQGWLKE IRKLQKSTHL LIRKLPFSRL AREICVKFTR GVDFNWQAQA LLALQEAAEA FLVHLFEDAY LLTLHAGRVT LFPKDVQLAR RIRGLEEGLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards