About Ubiquitin-conjugating enzyme E2 A
Ubiquitin-conjugating enzyme E2 A (UBE2A) is a protein
from Homo sapiens identified by UniProt accession
P49459, 152 residues long.
MolForge cross-references it against 0 known binders and
101 disease associations.
Target properties
| Protein name | Ubiquitin-conjugating enzyme E2 A |
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| UniProt accession | P49459 |
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| Gene | UBE2A |
|---|
| Organism | Homo sapiens |
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| Length | 152 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (101)
Diseases linked to this target (Open Targets).
- syndromic X-linked intellectual disability Nascimento type · score 0.73
- X-linked intellectual disability, Nascimento type · score 0.60
- X-linked non-syndromic intellectual disability · score 0.51
- neurodegenerative disease · score 0.49
- genetic disorder · score 0.46
- diffuse large B-cell lymphoma · score 0.35
- Neurodevelopmental delay · score 0.27
- clear cell renal carcinoma · score 0.18
- endometrial cancer · score 0.10
- Female infertility due to fertilization defect · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49459-F1 | alphafold | PREDICTED | 94.12 | — |
Amino-acid sequence (152 residues)
MSTPARRRLM RDFKRLQEDP PAGVSGAPSE NNIMVWNAVI FGPEGTPFED GTFKLTIEFT EEYPNKPPTV RFVSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS PANSQAAQLY QENKREYEKR VSAIVEQSWR DC
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