About Choline-phosphate cytidylyltransferase A
Choline-phosphate cytidylyltransferase A (PCYT1A) is a protein
from Homo sapiens identified by UniProt accession
P49585, 367 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Choline-phosphate cytidylyltransferase A |
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| UniProt accession | P49585 |
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| Gene | PCYT1A |
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| Organism | Homo sapiens |
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| Length | 367 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (85)
Diseases linked to this target (Open Targets).
- Spondylometaphyseal dysplasia - cone-rod dystrophy · score 0.81
- spondylometaphyseal dysplasia-cone-rod dystrophy syndrome · score 0.77
- neurodegenerative disease · score 0.46
- Leber congenital amaurosis · score 0.45
- genetic disorder · score 0.41
- Insulin resistance · score 0.37
- insulin resistance · score 0.37
- congenital generalized lipodystrophy · score 0.37
- cholestasis, progressive familial intrahepatic, 6 · score 0.36
- mean platelet volume · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49585-F1 | alphafold | PREDICTED | 76.00 | — |
Amino-acid sequence (367 residues)
MDAQCSAKVN ARKRRKEAPG PNGATEEDGV PSKVQRCAVG LRQPAPFSDE IEVDFSKPYV RVTMEEASRG TPCERPVRVY ADGIFDLFHS GHARALMQAK NLFPNTYLIV GVCSDELTHN FKGFTVMNEN ERYDAVQHCR YVDEVVRNAP WTLTPEFLAE HRIDFVAHDD IPYSSAGSDD VYKHIKEAGM FAPTQRTEGI STSDIITRIV RDYDVYARRN LQRGYTAKEL NVSFINEKKY HLQERVDKVK KKVKDVEEKS KEFVQKVEEK SIDLIQKWEE KSREFIGSFL EMFGPEGALK HMLKEGKGRM LQAISPKQSP SSSPTRERSP SPSFRWPFSG KTSPPCSPAN LSRHKAAAYD ISEDEED
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