Histidine--tRNA ligase, mitochondrial (HARS2)

About Histidine--tRNA ligase, mitochondrial

Histidine--tRNA ligase, mitochondrial (HARS2) is a protein from Homo sapiens identified by UniProt accession P49590, 506 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	Histidine--tRNA ligase, mitochondrial
UniProt accession	P49590
Gene	HARS2
Organism	Homo sapiens
Length	506 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

Perrault syndrome 2 · score 0.74
neurodegenerative disease · score 0.42
Perrault syndrome 1 · score 0.37
Sensorineural hearing impairment · score 0.37
sensorineural hearing loss · score 0.37
Perrault syndrome · score 0.27
genetic disorder · score 0.19
systolic blood pressure · score 0.06
deafness · score 0.05
depressive symptom measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49590-F1	alphafold	PREDICTED	88.08	—

Amino-acid sequence (506 residues)

MPLLGLLPRR AWASLLSQLL RPPCASCTGA VRCQSQVAEA VLTSQLKAHQ EKPNFIIKTP KGTRDLSPQH MVVREKILDL VISCFKRHGA KGMDTPAFEL KETLTEKYGE DSGLMYDLKD QGGELLSLRY DLTVPFARYL AMNKVKKMKR YHVGKVWRRE SPTIVQGRYR EFCQCDFDIA GQFDPMIPDA ECLKIMCEIL SGLQLGDFLI KVNDRRIVDG MFAVCGVPES KFRAICSSID KLDKMAWKDV RHEMVVKKGL APEVADRIGD YVQCHGGVSL VEQMFQDPRL SQNKQALEGL GDLKLLFEYL TLFGIADKIS FDLSLARGLD YYTGVIYEAV LLQTPTQAGE EPLNVGSVAA GGRYDGLVGM FDPKGHKVPC VGLSIGVERI FYIVEQRMKT KGEKVRTTET QVFVATPQKN FLQERLKLIA ELWDSGIKAE MLYKNNPKLL TQLHYCESTG IPLVVIIGEQ ELKEGVIKIR SVASREEVAI KRENFVAEIQ KRLSES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards