About Serine--tRNA ligase, cytoplasmic
Serine--tRNA ligase, cytoplasmic (SARS1) is a protein
from Homo sapiens identified by UniProt accession
P49591, 514 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Serine--tRNA ligase, cytoplasmic |
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| UniProt accession | P49591 |
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| Gene | SARS1 |
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| Organism | Homo sapiens |
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| Length | 514 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (46)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with microcephaly, ataxia, and seizures · score 0.66
- autosomal recessive non-syndromic intellectual disability · score 0.37
- autosomal recessive primary microcephaly · score 0.37
- Cerebral arteriovenous malformation · score 0.34
- neutrophil count · score 0.05
- apolipoprotein A 1 measurement · score 0.04
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.04
- iridocorneal endothelial syndrome · score 0.04
- X-linked intellectual disability-retinitis pigmentosa syndrome · score 0.04
- Tietz syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49591-F1 | alphafold | PREDICTED | 93.37 | — |
Amino-acid sequence (514 residues)
MVLDLDLFRV DKGGDPALIR ETQEKRFKDP GLVDQLVKAD SEWRRCRFRA DNLNKLKNLC SKTIGEKMKK KEPVGDDESV PENVLSFDDL TADALANLKV SQIKKVRLLI DEAILKCDAE RIKLEAERFE NLREIGNLLH PSVPISNDED VDNKVERIWG DCTVRKKYSH VDLVVMVDGF EGEKGAVVAG SRGYFLKGVL VFLEQALIQY ALRTLGSRGY IPIYTPFFMR KEVMQEVAQL SQFDEELYKV IGKGSEKSDD NSYDEKYLIA TSEQPIAALH RDEWLRPEDL PIKYAGLSTC FRQEVGSHGR DTRGIFRVHQ FEKIEQFVYS SPHDNKSWEM FEEMITTAEE FYQSLGIPYH IVNIVSGSLN HAASKKLDLE AWFPGSGAFR ELVSCSNCTD YQARRLRIRY GQTKKMMDKV EFVHMLNATM CATTRTICAI LENYQTEKGI TVPEKLKEFM PPGLQELIPF VKPAPIEQEP SKKQKKQHEG SKKKAAARDV TLENRLQNME VTDA
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