About Protein phosphatase 1F
Protein phosphatase 1F (PPM1F) is a protein
from Homo sapiens identified by UniProt accession
P49593, 454 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Protein phosphatase 1F |
|---|
| UniProt accession | P49593 |
|---|
| Gene | PPM1F |
|---|
| Organism | Homo sapiens |
|---|
| Length | 454 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (56)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- hemoglobin measurement · score 0.15
- age at menarche · score 0.15
- erythrocyte count · score 0.14
- hematocrit · score 0.13
- red blood cell density measurement · score 0.12
- age at menopause · score 0.10
- hepatocellular carcinoma · score 0.09
- testosterone measurement · score 0.08
- unipolar depression · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49593-F1 | alphafold | PREDICTED | 87.40 | — |
Amino-acid sequence (454 residues)
MSSGAPQKSS PMASGAEETP GFLDTLLQDF PALLNPEDPL PWKAPGTVLS QEEVEGELAE LAMGFLGSRK APPPLAAALA HEAVSQLLQT DLSEFRKLPR EEEEEEEDDD EEEKAPVTLL DAQSLAQSFF NRLWEVAGQW QKQVPLAARA SQRQWLVSIH AIRNTRRKME DRHVSLPSFN QLFGLSDPVN RAYFAVFDGH GGVDAARYAA VHVHTNAARQ PELPTDPEGA LREAFRRTDQ MFLRKAKRER LQSGTTGVCA LIAGATLHVA WLGDSQVILV QQGQVVKLME PHRPERQDEK ARIEALGGFV SHMDCWRVNG TLAVSRAIGD VFQKPYVSGE ADAASRALTG SEDYLLLACD GFFDVVPHQE VVGLVQSHLT RQQGSGLRVA EELVAAARER GSHDNITVMV VFLRDPQELL EGGNQGEGDP QAEGRRQDLP SSLPEPETQA PPRS
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