Homeobox even-skipped homolog protein 1 (EVX1)

About Homeobox even-skipped homolog protein 1

Homeobox even-skipped homolog protein 1 (EVX1) is a protein from Homo sapiens identified by UniProt accession P49640, 407 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	Homeobox even-skipped homolog protein 1
UniProt accession	P49640
Gene	EVX1
Organism	Homo sapiens
Length	407 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.40
diastolic blood pressure · score 0.40
alcohol consumption measurement · score 0.39
alcohol drinking · score 0.39
mean arterial pressure · score 0.38
hypertension · score 0.37
pulse pressure measurement · score 0.30
Diuretic use measurement · score 0.29
drug use measurement · score 0.24
vital capacity · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49640-F1	alphafold	PREDICTED	56.18	—

Amino-acid sequence (407 residues)

MESRKDMVVF LDGGQLGTLV GKRVSNLSEA VGSPLPEPPE KMVPRGCLSP RAVPPATRER GGGGPEEEPV DGLAGSAAGP GAEPQVAGAA MLGPGPPAPS VDSLSGQGQP SSSDTESDFY EEIEVSCTPD CATGNAEYQH SKGSGSEALV GSPNGGSETP KSNGGSGGGG SQGTLACSAS DQMRRYRTAF TREQIARLEK EFYRENYVSR PRRCELAAAL NLPETTIKVW FQNRRMKDKR QRLAMTWPHP ADPAFYTYMM SHAAAAGGLP YPFPSHLPLP YYSPVGLGAA SAASAAASPF SGSLRPLDTF RVLSQPYPRP ELLCAFRHPP LYPGPAHGLG ASAGGPCSCL ACHSGPANGL APRAAAASDF TCASTSRSDS FLTFAPSVLS KASSVALDQR EEVPLTR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards