DNA primase large subunit (PRIM2)

About DNA primase large subunit

DNA primase large subunit (PRIM2) is a protein from Homo sapiens identified by UniProt accession P49643, 509 residues long. MolForge cross-references it against 0 known binders and 307 disease associations.

Target properties

Protein name	DNA primase large subunit
UniProt accession	P49643
Gene	PRIM2
Organism	Homo sapiens
Length	509 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (307)

Diseases linked to this target (Open Targets).

acute myeloid leukemia · score 0.60
non-small cell lung carcinoma · score 0.60
acute lymphoblastic leukemia · score 0.60
pancreatic carcinoma · score 0.59
chronic lymphocytic leukemia · score 0.59
ovarian carcinoma · score 0.57
breast carcinoma · score 0.57
adult acute lymphoblastic leukemia · score 0.56
leukemia · score 0.56
neoplasm · score 0.56

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49643-F1	alphafold	PREDICTED	80.63	—

Amino-acid sequence (509 residues)

MEFSGRKWRK LRLAGDQRNA SYPHCLQFYL QPPSENISLI EFENLAIDRV KLLKSVENLG VSYVKGTEQY QSKLESELRK LKFSYRENLE DEYEPRRRDH ISHFILRLAY CQSEELRRWF IQQEMDLLRF RFSILPKDKI QDFLKDSQLQ FEAISDEEKT LREQEIVASS PSLSGLKLGF ESIYKIPFAD ALDLFRGRKV YLEDGFAYVP LKDIVAIILN EFRAKLSKAL ALTARSLPAV QSDERLQPLL NHLSHSYTGQ DYSTQGNVGK ISLDQIDLLS TKSFPPCMRQ LHKALRENHH LRHGGRMQYG LFLKGIGLTL EQALQFWKQE FIKGKMDPDK FDKGYSYNIR HSFGKEGKRT DYTPFSCLKI ILSNPPSQGD YHGCPFRHSD PELLKQKLQS YKISPGGISQ ILDLVKGTHY QVACQKYFEM IHNVDDCGFS LNHPNQFFCE SQRILNGGKD IKKEPIQPET PQPKPSVQKT KDASSALASL NSSLEMDMEG LEDYFSEDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards