About Caspase-4
Caspase-4 (CASP4) is a protein
from Homo sapiens identified by UniProt accession
P49662, 377 residues long.
MolForge cross-references it against 0 known binders and
253 disease associations.
Target properties
| Protein name | Caspase-4 |
|---|
| UniProt accession | P49662 |
|---|
| Gene | CASP4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 377 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (253)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.30
- neoplasm · score 0.11
- non-small cell lung carcinoma · score 0.11
- medical procedure · score 0.09
- aneurysm · score 0.09
- cirrhosis of liver · score 0.09
- nonpapillary renal cell carcinoma · score 0.08
- non-alcoholic steatohepatitis · score 0.08
- risk-taking behaviour · score 0.08
- infection · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49662-F1 | alphafold | PREDICTED | 78.35 | — |
Amino-acid sequence (377 residues)
MAEGNHRKKP LKVLESLGKD FLTGVLDNLV EQNVLNWKEE EKKKYYDAKT EDKVRVMADS MQEKQRMAGQ MLLQTFFNID QISPNKKAHP NMEAGPPESG ESTDALKLCP HEEFLRLCKE RAEEIYPIKE RNNRTRLALI ICNTEFDHLP PRNGADFDIT GMKELLEGLD YSVDVEENLT ARDMESALRA FATRPEHKSS DSTFLVLMSH GILEGICGTV HDEKKPDVLL YDTIFQIFNN RNCLSLKDKP KVIIVQACRG ANRGELWVRD SPASLEVASS QSSENLEEDA VYKTHVEKDF IAFCSSTPHN VSWRDSTMGS IFITQLITCF QKYSWCCHLE EVFRKVQQSF ETPRAKAQMP TIERLSMTRY FYLFPGN
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