About Casein kinase I isoform epsilon
Casein kinase I isoform epsilon (CSNK1E) is a protein
from Homo sapiens identified by UniProt accession
P49674, 416 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | Casein kinase I isoform epsilon |
|---|
| UniProt accession | P49674 |
|---|
| Gene | CSNK1E |
|---|
| Organism | Homo sapiens |
|---|
| Length | 416 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (109)
Diseases linked to this target (Open Targets).
- follicular lymphoma · score 0.54
- marginal zone B-cell lymphoma · score 0.46
- neoplasm · score 0.39
- chronic lymphocytic leukemia · score 0.38
- neurodegenerative disease · score 0.37
- infantile epileptic-dyskinetic encephalopathy · score 0.33
- developmental and epileptic encephalopathy, 1 · score 0.33
- West syndrome · score 0.33
- developmental and epileptic encephalopathy · score 0.33
- Spasticity - intellectual disability - X-linked epilepsy · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49674-F1 | alphafold | PREDICTED | 79.20 | — |
Amino-acid sequence (416 residues)
MELRVGNKYR LGRKIGSGSF GDIYLGANIA SGEEVAIKLE CVKTKHPQLH IESKFYKMMQ GGVGIPSIKW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFST YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGAARN PEDVDRERRE HEREERMGQL RGSATRALPP GPPTGATANR LRSAAEPVAS TPASRIQPAG NTSPRAISRV DRERKVSMRL HRGAPANVSS SDLTGRQEVS RIPASQTSVP FDHLGK
Explore Casein kinase I isoform epsilon with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets