C-X-C chemokine receptor type 3 (CXCR3)

About C-X-C chemokine receptor type 3

C-X-C chemokine receptor type 3 (CXCR3) is a protein from Homo sapiens identified by UniProt accession P49682, 368 residues long. MolForge cross-references it against 0 known binders and 762 disease associations.

Target properties

Protein name	C-X-C chemokine receptor type 3
UniProt accession	P49682
Gene	CXCR3
Organism	Homo sapiens
Length	368 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (762)

Diseases linked to this target (Open Targets).

ovarian cancer · score 0.27
breast adenocarcinoma · score 0.17
head and neck squamous cell carcinoma · score 0.17
neoplasm · score 0.12
infection · score 0.11
infect · score 0.11
Rheumatoid arthritis · score 0.11
melanoma · score 0.10
myeloid sarcoma · score 0.10
breast cancer · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49682-F1	alphafold	PREDICTED	80.54	—

Amino-acid sequence (368 residues)

MVLEVSDHQV LNDAEVAALL ENFSSSYDYG ENESDSCCTS PPCPQDFSLN FDRAFLPALY SLLFLLGLLG NGAVAAVLLS RRTALSSTDT FLLHLAVADT LLVLTLPLWA VDAAVQWVFG SGLCKVAGAL FNINFYAGAL LLACISFDRY LNIVHATQLY RRGPPARVTL TCLAVWGLCL LFALPDFIFL SAHHDERLNA THCQYNFPQV GRTALRVLQL VAGFLLPLLV MAYCYAHILA VLLVSRGQRR LRAMRLVVVV VVAFALCWTP YHLVVLVDIL MDLGALARNC GRESRVDVAK SVTSGLGYMH CCLNPLLYAF VGVKFRERMW MLLLRLGCPN QRGLQRQPSS SRRDSSWSET SEASYSGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards