Prolactin-releasing peptide receptor (PRLHR)

About Prolactin-releasing peptide receptor

Prolactin-releasing peptide receptor (PRLHR) is a protein from Homo sapiens identified by UniProt accession P49683, 370 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.

Target properties

Protein name	Prolactin-releasing peptide receptor
UniProt accession	P49683
Gene	PRLHR
Organism	Homo sapiens
Length	370 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (97)

Diseases linked to this target (Open Targets).

body fat percentage · score 0.37
pancreatic carcinoma · score 0.26
glioblastoma multiforme · score 0.25
ovarian cancer · score 0.25
triglyceride measurement · score 0.25
head and neck squamous cell carcinoma · score 0.16
appendicular lean mass · score 0.13
medulloblastoma · score 0.13
adolescent idiopathic scoliosis · score 0.13
body height · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49683-F1	alphafold	PREDICTED	80.55	—

Amino-acid sequence (370 residues)

MASSTTRGPR VSDLFSGLPP AVTTPANQSA EASAGNGSVA GADAPAVTPF QSLQLVHQLK GLIVLLYSVV VVVGLVGNCL LVLVIARVRR LHNVTNFLIG NLALSDVLMC TACVPLTLAY AFEPRGWVFG GGLCHLVFFL QPVTVYVSVF TLTTIAVDRY VVLVHPLRRR ISLRLSAYAV LAIWALSAVL ALPAAVHTYH VELKPHDVRL CEEFWGSQER QRQLYAWGLL LVTYLLPLLV ILLSYVRVSV KLRNRVVPGC VTQSQADWDR ARRRRTFCLL VVIVVVFAVC WLPLHVFNLL RDLDPHAIDP YAFGLVQLLC HWLAMSSACY NPFIYAWLHD SFREELRKLL VAWPRKIAPH GQNMTVSVVI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards