G-protein coupled receptor 15 (GPR15)

About G-protein coupled receptor 15

G-protein coupled receptor 15 (GPR15) is a protein from Homo sapiens identified by UniProt accession P49685, 360 residues long. MolForge cross-references it against 0 known binders and 236 disease associations.

Target properties

Protein name	G-protein coupled receptor 15
UniProt accession	P49685
Gene	GPR15
Organism	Homo sapiens
Length	360 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (236)

Diseases linked to this target (Open Targets).

ulcerative colitis · score 0.09
neoplasm · score 0.08
cancer · score 0.08
myocardial infarction · score 0.08
isolated agammaglobulinemia · score 0.07
colitis · score 0.07
common variable immunodeficiency · score 0.07
T-B+ severe combined immunodeficiency due to JAK3 deficiency · score 0.06
Immunodeficiency by defective expression of HLA class 2 · score 0.06
Autosomal recessive early-onset inflammatory bowel disease · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49685-F1	alphafold	PREDICTED	81.85	—

Amino-acid sequence (360 residues)

MDPEETSVYL DYYYATSPNS DIRETHSHVP YTSVFLPVFY TAVFLTGVLG NLVLMGALHF KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR TGSFLCKGSS YMISVNMHCS VLLLTCMSVD RYLAIVWPVV SRKFRRTDCA YVVCASIWFI SCLLGLPTLL SRELTLIDDK PYCAEKKATP IKLIWSLVAL IFTFFVPLLS IVTCYCCIAR KLCAHYQQSG KHNKKLKKSI KIIFIVVAAF LVSWLPFNTF KFLAIVSGLR QEHYLPSAIL QLGMEVSGPL AFANSCVNPF IYYIFDSYIR RAIVHCLCPC LKNYDFGSST ETSDSHLTKA LSTFIHAEDF ARRRKRSVSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards