ADP-ribosylation factor-like protein 4D (ARL4D)

About ADP-ribosylation factor-like protein 4D

ADP-ribosylation factor-like protein 4D (ARL4D) is a protein from Homo sapiens identified by UniProt accession P49703, 201 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.

Target properties

Protein name	ADP-ribosylation factor-like protein 4D
UniProt accession	P49703
Gene	ARL4D
Organism	Homo sapiens
Length	201 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (36)

Diseases linked to this target (Open Targets).

protein measurement · score 0.32
cataract · score 0.13
Age-related cataract · score 0.11
Mobius syndrome · score 0.07
type 2 diabetes mellitus · score 0.07
neoplasm · score 0.06
neutrophil count · score 0.05
colitis · score 0.02
infection · score 0.02
infect · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49703-F1	alphafold	PREDICTED	89.90	—

Amino-acid sequence (201 residues)

MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV PTKGFNTEKI RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV VDAAEAERLE EAKVELHRIS RASDNQGVPV LVLANKQDQP GALSAAEVEK RLAVRELAAA TLTHVQGCSA VDGLGLQQGL ERLYEMILKR KKAARGGKKR R

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards