About Transcriptional repressor CTCF
Transcriptional repressor CTCF (CTCF) is a protein
from Homo sapiens identified by UniProt accession
P49711, 727 residues long.
MolForge cross-references it against 0 known binders and
413 disease associations.
Target properties
| Protein name | Transcriptional repressor CTCF |
|---|
| UniProt accession | P49711 |
|---|
| Gene | CTCF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 727 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (413)
Diseases linked to this target (Open Targets).
- intellectual disability-feeding difficulties-developmental delay-microcephaly syndrome · score 0.77
- Intellectual disability · score 0.63
- genetic disorder · score 0.53
- endometrial cancer · score 0.50
- breast adenocarcinoma · score 0.45
- acute lymphoblastic leukemia · score 0.42
- medulloblastoma · score 0.39
- syndromic intellectual disability · score 0.37
- colorectal adenocarcinoma · score 0.37
- Endometrial Endometrioid Adenocarcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P49711-F1 | alphafold | PREDICTED | 58.81 | — |
Amino-acid sequence (727 residues)
MEGDAVEAIV EESETFIKGK ERKTYQRRRE GGQEEDACHL PQNQTDGGEV VQDVNSSVQM VMMEQLDPTL LQMKTEVMEG TVAPEAEAAV DDTQIITLQV VNMEEQPINI GELQLVQVPV PVTVPVATTS VEELQGAYEN EVSKEGLAES EPMICHTLPL PEGFQVVKVG ANGEVETLEQ GELPPQEDPS WQKDPDYQPP AKKTKKTKKS KLRYTEEGKD VDVSVYDFEE EQQEGLLSEV NAEKVVGNMK PPKPTKIKKK GVKKTFQCEL CSYTCPRRSN LDRHMKSHTD ERPHKCHLCG RAFRTVTLLR NHLNTHTGTR PHKCPDCDMA FVTSGELVRH RRYKHTHEKP FKCSMCDYAS VEVSKLKRHI RSHTGERPFQ CSLCSYASRD TYKLKRHMRT HSGEKPYECY ICHARFTQSG TMKMHILQKH TENVAKFHCP HCDTVIARKS DLGVHLRKQH SYIEQGKKCR YCDAVFHERY ALIQHQKSHK NEKRFKCDQC DYACRQERHM IMHKRTHTGE KPYACSHCDK TFRQKQLLDM HFKRYHDPNF VPAAFVCSKC GKTFTRRNTM ARHADNCAGP DGVEGENGGE TKKSKRGRKR KMRSKKEDSS DSENAEPDLD DNEDEEEPAV EIEPEPEPQP VTPAPPPAKK RRGRPPGRTN QPKQNQPTAI IQVEDQNTGA IENIIVEVKK EPDAEPAEGE EEEAQPAATD APNGDLTPEM ILSMMDR
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