CCAAT/enhancer-binding protein alpha (CEBPA)

About CCAAT/enhancer-binding protein alpha

CCAAT/enhancer-binding protein alpha (CEBPA) is a protein from Homo sapiens identified by UniProt accession P49715, 358 residues long. MolForge cross-references it against 0 known binders and 815 disease associations.

Target properties

Protein name	CCAAT/enhancer-binding protein alpha
UniProt accession	P49715
Gene	CEBPA
Organism	Homo sapiens
Length	358 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (815)

Diseases linked to this target (Open Targets).

acute myeloid leukemia · score 0.82
erythrocyte count · score 0.45
BMI-adjusted waist-hip ratio · score 0.44
apolipoprotein A 1 measurement · score 0.42
mean corpuscular volume · score 0.40
red blood cell density measurement · score 0.40
high density lipoprotein cholesterol measurement · score 0.40
hereditary neoplastic syndrome · score 0.39
Inherited cancer-predisposing syndrome · score 0.39
basophil count · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P49715-F1	alphafold	PREDICTED	61.70	—

Amino-acid sequence (358 residues)

MESADFYEAE PRPPMSSHLQ SPPHAPSSAA FGFPRGAGPA QPPAPPAAPE PLGGICEHET SIDISAYIDP AAFNDEFLAD LFQHSRQQEK AKAAVGPTGG GGGGDFDYPG APAGPGGAVM PGGAHGPPPG YGCAAAGYLD GRLEPLYERV GAPALRPLVI KQEPREEDEA KQLALAGLFP YQPPPPPPPS HPHPHPPPAH LAAPHLQFQI AHCGQTTMHL QPGHPTPPPT PVPSPHPAPA LGAAGLPGPG SALKGLGAAH PDLRASGGSG AGKAKKSVDK NSNEYRVRRE RNNIAVRKSR DKAKQRNVET QQKVLELTSD NDRLRKRVEQ LSRELDTLRG IFRQLPESSL VKAMGNCA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards